TY  - JOUR
AU  - Bradshaw, CS
AU  - Morton, AN
AU  - Hocking, J
AU  - Garland, SM
AU  - Morris, MB
AU  - Moss, LM
AU  - Horvath, LB
AU  - Kuzevska, I
AU  - Fairley, CK
Y2  - 2014/05/21
Y2  - 2005/12/28
Y2  - 2005/12/28
Y2  - 2005/12/28
Y2  - 2005/12/28
Y2  - 2005/12/28
Y2  - 2005/12/28
Y2  - 2005/12/28
Y2  - 2005/12/28
Y2  - 2005/12/28
Y2  - 2005/12/28
Y2  - 2005/12/28
Y2  - 2005/12/28
Y2  - 2005/12/28
Y2  - 2005/12/28
Y1  - 2006/06/01
SN  - 0022-1899
UR  - http://hdl.handle.net/11343/26393
AB  - BACKGROUND: We wished to determine recurrences of bacterial vaginosis (BV) after treatment over the course of 12 months and to establish factors associated with recurrence. METHODS: Women with symptomatic BV (a Nugent score [NS] of 7-10 or of 4-6 with >or=3 Amsel criteria) were enrolled. BV was treated with 400 mg of oral metronidazole twice a day for 7 days. Participants completed a questionnaire and vaginal swabs were collected at 1, 3, 6, and 12 months; the study end point was an NS of 7-10. RESULTS: A total of 121 (87%) women with an NS of 7-10 and 18 (13%) with an NS of 4-6 and >or=3 Amsel criteria were enrolled; 130 (94%) returned >or=1 vaginal samples. Sixty-eight women (58% [95% confidence interval {CI}, 49%-66%]) had a recurrence of BV (NS 7-10), and 84 (69% [95% CI, 61%-77%]) had a recurrence of abnormal vaginal flora (NS 4-10) by 12 months. A past history of BV, a regular sex partner throughout the study, and female sex partners were significantly associated with recurrence of BV and abnormal vaginal flora by multivariate analysis; the use of hormonal contraception had a negative association with recurrence. CONCLUSION: Current recommended treatment is not preventing the recurrence of BV or abnormal vaginal flora in the majority of women; factors associated with recurrence support a possible role for sexual transmission in the pathogenesis of recurrent BV.
LA  - English
PB  - OXFORD UNIV PRESS INC
KW  - Preventive Medicine; Women's Health; Preventive Medicine
T1  - High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence
DO  - 10.1086/503780
IS  - JOURNAL OF INFECTIOUS DISEASES
VL  - 193
IS  - 11
SP  - 1478-1486
L1  - /bitstream/handle/11343/26393/116183_5233.pdf?sequence=1&isAllowed=n
ER  -