TY  - JOUR
AU  - Toan, NL
AU  - Song, LH
AU  - Kremsner, PG
AU  - Duy, DN
AU  - Binh, VQ
AU  - Koeberlein, B
AU  - Kaiser, S
AU  - Kandolf, R
AU  - Torresi, J
AU  - Bock, C-T
Y2  - 2014/05/21
Y1  - 2006/06/01
SN  - 0270-9139
UR  - http://hdl.handle.net/11343/26611
AB  - Eight genotypes (A-H) of hepatitis B virus (HBV) have been identified. However, the impact of different genotypes on the clinical course of hepatitis B infection remains controversial. We investigated the frequency and clinical outcome of HBV genotypes and genotype mixtures in HBV-infected patients from Vietnam, Europe, and Africa. In addition, we analyzed the effects of genotype mixtures on alterations in in vitro viral replication. In Asian patients, seven genotypes (A-G) were detected, with A, C, and D predominating. In European and African patients, only genotypes A, C, D, and G were identified. Genotype mixtures were more frequently encountered in African than in Asian (P = .01) and European patients (P = .06). In Asian patients, the predominant genotype mixtures included A/C and C/D, compared to C/D in European and A/D in African patients. Genotype A was more frequent in asymptomatic compared with symptomatic patients (P < .0001). Genotype C was more frequent in patients with hepatocellular carcinoma (HCC; P = .02). Genotype mixtures were more frequently encountered in patients with chronic hepatitis in comparison to patients with acute hepatitis B (P = .015), liver cirrhosis (P = .013), and HCC (P = .002). Viral loads in patients infected with genotype mixtures were significantly higher in comparison to patients with a single genotype (P = .019). Genotype mixtures were also associated with increased in vitro HBV replication. In conclusion, infection with mixtures of HBV genotypes is frequent in Asia, Africa, and Europe. Differences in the replication-phenotype of single genotypes compared to genotype-mixtures suggest that co-infection with different HBV-genotypes is associated with altered pathogenesis and clinical outcome.
N1  - application/pdf
LA  - English
PB  - WILEY
KW  - Infectious Diseases; Infectious Diseases
T1  - Impact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in Vietnam
DO  - 10.1002/hep.21188
IS  - Hepatology
VL  - 43
IS  - 6
SP  - 1375-1384
L1  - /bitstream/handle/11343/26611/116822_5465.pdf?sequence=1&isAllowed=n
ER  -