TY  - JOUR
AU  - Gouskos, T
AU  - Wightman, F
AU  - Chang, J
AU  - Earnest-Silveira, L
AU  - Sasadeusz, J
AU  - Lewis, SR
AU  - Torresi, J
Y2  - 2014/05/21
Y1  - 2004/08/20
SN  - 0269-9370
UR  - http://hdl.handle.net/11343/26613
AB  - We describe here a severe flare of hepatitis caused by lamivudine-resistant hepatitis B virus(HBV) in an HIV/HBV co-infected individual.Lamivudine-resistant HBV was detected 6 months before the development of severe hepatitis. Sequencing of the HBV genome isolated from the patients' serum did not identify compensatory mutations in the HBV polymerase that may have restored viral replication. However, a strong HBV-specific CD8 T-cell response was identified and may have resulted in the severe hepatitis.
N1  - application/pdf
LA  - English
PB  - LIPPINCOTT WILLIAMS & WILKINS
KW  - Infectious Diseases; Infectious Diseases
T1  - Severe hepatitis and prolonged hepatitis B virus-specific CD8 T-cell response after selection of hepatitis B virus YMDD variant in an HIV/hepatitis B virus-co-infected patient
DO  - 10.1097/01.aids.0000131384.53350.59
IS  - AIDS
VL  - 18
IS  - 12
SP  - 1734-1737
L1  - /bitstream/handle/11343/26613/116824_5467.pdf?sequence=1&isAllowed=n
ER  -