TY  - JOUR
AU  - Brown, M.
AU  - Shepherd, R. K.
AU  - Webster, W. R.
AU  - Martin, R. L.
AU  - Clark, Graeme M.
Y2  - 2014/05/21
Y1  - 1992
UR  - http://hdl.handle.net/11343/27353
AB  - The 2-deoxyglucose (2-DG) technique was used to study the cochleotopic selectivity of a multichannel scala tympani electrode array in four cats with another acting as an unstimulated control. Each animal was unilaterally deafened and a multichannel electrode array inserted 6 mm into the scala tympani. Thresholds to electrical stimulation were determined by recording electrically evoked auditory brainstem responses (EABRs). Each animal was injected with 2-DG, and electrically stimulated using bipolar electrodes located either distal or proximal to the round window. The contralateral- ear was stimulated with acoustic tone pips at frequencies that matched the electrode place. Stimulation of both distal and proximal bipolar electrodes at 3X EABR threshold, evoked localized 2-DG labelling in both ipsilateral cochlear nucleus (CN) and the contralateral inferior colliculus (IC), which was very similar in orientation and breadth to labelling evoked by the contralateral tone pips. The cochleotopic position of labelling to proximal stimulation was located in the 24-26 kHz region of each structure, whereas the distal labelling was located around 12 kHz. Distal stimulation at 10 X EABR threshold produced very broad 2-DG labelling in IC centered around the 12 kHz place. The present 2-DG results clearly illustrate cochleotopic selectivity using multichannel bipolar scala tympani electrodes. The extent of this selectivity is dependent on electrical stimulus levels. The 2-DG technique has great potential in evaluating the efficacy of new electrode array designs.
KW  - cochlear prostheses
KW  - 2-deoxygluscose
KW  - electrical stimulation
KW  - cochlear nucleus
KW  - inferior colliculus
T1  - Cochleotopic selectivity of a multichannel scala tympani electrode array using the 2-deoxyglucose technique
IS  - Hearing Research
VL  - 59
SP  - 224-240
L1  - /bitstream/handle/11343/27353/119335_vol6_333.pdf?sequence=1&isAllowed=n
ER  -