TY  - JOUR
AU  - Marzella, P. L.
AU  - Clark, Graeme M.
AU  - Shepherd, R. K.
AU  - Bartlett, P. F.
AU  - Kilpatrick, T. J.
Y2  - 2014/05/21
Y1  - 1998
UR  - http://hdl.handle.net/11343/27520
AB  - Transforming growth factor-βs (TGF-βs) have been implicated in normal inner ear development and in promoting neuronal survival. Early rat post-natal spiral ganglion cells (SGC) in dissociated cell culture were used as a model of auditory innervation to test the trophic factors TGF-βs and neurotrophin-3 (NT-3) for their ability, individually or in combination, to promote neuronal survival. The findings from this study suggest that TGF-βs supports neuronal survival in a concentration-dependent manner. Moreover TGF-βs and NT-3-potentiated spiral ganglion neuronal survival in a synergistic fashion.
KW  - otolaryngology
KW  - auditory neurones
KW  - pharmacological therapy
KW  - cytokine
KW  - neurotrophin
KW  - neuronal degeneration
KW  - neurotrophic effects
T1  - Synergy between TGF-ß3 and NT-3 to promote the survival of spiral ganglia neurones in vitro
IS  - Neuroscience Letters
VL  - 240
SP  - 77-80
L1  - /bitstream/handle/11343/27520/119502_vol11_1125.pdf?sequence=1&isAllowed=n
ER  -