TY  - JOUR
AU  - Wei, Benjamin P. C.
AU  - Robins-Browne, Roy M.
AU  - Shepherd, Robert K.
AU  - AZZOPARDI, KRISTY
AU  - Clark, Graeme M.
AU  - O'Leary, Stephen J.
Y2  - 2014/05/21
Y1  - 2006
UR  - http://hdl.handle.net/11343/27631
AB  - Objectives: To determine whether ciprofloxacin retains its antimicrobial activity after storage with Healon at ambient temperature and at 37°C over 5 weeks and then to establish whether the application of ciprofloxacin/Healon onto scala tympani electrode arrays reduces the risk of meningitis in implanted rats inoculated with S. pneumoniae.    
                        
                    Study Design: In vitro laboratory and in vivo animal studies    
                        
                    Methods: The antibacterial activity of three concentrations of ciprofloxacin/Healon (7.5, 75, and 750 µg/mL) was examined over 5 weeks at both ambient temperature (23°C) and body temperature (37°C). Thirty-six rats (18 implanted with ciprofloxacin [750 mg/mL]/Healon-coated electrode array and 18 without the coating) were infected with S. pneumoniae 4 weeks after implantation by way of three different routes of infection (hematogenous, middle ear, and inner ear) and observed for the development of meningitis.    
                        
                    Results: The antibacterial activity of ciprofloxacin/Healon was maintained over 5 weeks at both 23°C and 37°C. The implanted rats with the ciprofloxacin/Healon-coated electrode array were protected from meningitis when the bacteria were given by way of the hematogenous route (Fisher’s exact test, P = .008) but not when the bacteria were inoculated directly into the middle or inner ear. However, the time to develop meningitis was significantly longer in rats implanted with a coated array, irrespective of the route of inoculation (P < .05, log rank test).    
                        
                    Conclusion: Our animal model demonstrated that a ciprofloxacin-coated electrode array can protect healthy implanted rats from meningitis when the route of infection is hematogenous and can delay the onset of meningitis when bacteria are inoculated directly into the middle or inner ear.
KW  - ciprofloxacin
KW  - sodium hyaluronate
KW  - pneumococcal meningitis
KW  - cochlear implantation
KW  - Streptococcus pneumoniae
T1  - Protective effects of local administration of ciprofloxacin on the risk of pneumococccal meningitis after cochlear implantation
IS  - The Laryngoscope
VL  - 116
IS  - 12
SP  - 2138-2144
L1  - /bitstream/handle/11343/27631/119613_vol14_1692.pdf?sequence=1&isAllowed=n
ER  -