TY  - JOUR
AU  - Wei, Benjamin P. C.
AU  - Robins-Browne, Roy M.
AU  - Shepherd, Robert K.
AU  - AZZOPARDI, KRISTY
AU  - Clark, Graeme M.
AU  - O'Leary, Stephen J.
Y2  - 2014/05/21
Y1  - 2007
UR  - http://hdl.handle.net/11343/27634
AB  - Objectives:   To examine if a 23-valent pneumococcal capsular polysaccharide vaccine (PPV23) reduces the risk of meningitis in healthy rats after cochlear implantation.
                        
                    Design:   Interventional animal study.  
                        
                    Interventions:   Thirty-six rats (18 immunized and 18 unimmunized) received cochlear implantations and were then infected with Streptococcus pneumoniae via 3 different routes (hematogenous, middle ear, and inner ear) in numbers sufficient to induce meningitis.  
                        
                    Results:   The rats with implants that received PPV23 were protected from meningitis when the bacteria were delivered via the hematogenous and middle-ear routes (Fisher exact test P<.05). However, the protective effect of the vaccine in the rats with implants was only moderate when the bacteria were inoculated directly into the inner ear.  
                        
                    Conclusions:   Our animal model clearly demonstrates that immunization can protect healthy rats with a cochlear implant from meningitis caused by a vaccine-covered serotype.  This finding supports the notion that all current and future implant recipients should be vaccinated against S pneumoniae.
KW  - cochlear implants
KW  - otolaryngology
KW  - otology
T1  - Assessment of the protective effect of pneumococcal vaccination in preventing meningitis after cochlear implantation
IS  - Archives of Otolaryngology - Head and Neck Surgery
VL  - 133
IS  - 10
SP  - 987-994
L1  - /bitstream/handle/11343/27634/119616_vol14_1695.pdf?sequence=1&isAllowed=n
ER  -