TY  - JOUR
AU  - Shen, AJJ
AU  - King, J
AU  - Colman, PG
AU  - Yates, CJ
Y2  - 2021/10/25
Y1  - 2021/09
SN  - 2399-5262
UR  - http://hdl.handle.net/11343/289877
AB  - Adrenocorticotropic hormone (ACTH)-secreting pituitary carcinomas (PC) are rare. The natural history and management of these carcinomas are poorly understood. We conducted a literature review using The MEDLINE database, including the search terms; ‘ACTH’ and ‘pituitary carcinoma’. We also describe in detail a case of ACTH-secreting PC. A total of 61 case reports were reviewed. Median age of diagnosis was 45 years (IQR: 34–54). Metastases to multiple organs were common (61%). Adjuvant therapy especially radiotherapy (78%), temozolomide (34%) and other medical therapy (29%) were frequently employed. The mortality was 53% with a median time to death from diagnosis of 1 year (IQR: 1–3). In conclusion, ACTH-secreting PC are associated with high mortality and a multidisciplinary team approach is recommended for optimal care due to the emerging modalities with possible efficacy.
LA  - en
PB  - Future Medicine Ltd
T1  - Diagnosis and management of adrenocorticotropic hormone-secreting pituitary carcinoma: a case report and review of the literature
DO  - 10.2217/frd-2021-0007
IS  - Future Rare Diseases
VL  - 1
IS  - 3
SP  - frd13-
L1  - /bitstream/handle/11343/289877/www.futuremedicine.com-doi-reader-10.2217-frd-2021-0007.pdf?sequence=1&isAllowed=y
ER  -