TY  - JOUR
AU  - Richardson, RT
AU  - Wise, AK
AU  - Thompson, BC
AU  - Flynn, BO
AU  - Atkinson, PJ
AU  - Fretwell, NJ
AU  - Fallon, JB
AU  - Wallace, GG
AU  - Shepherd, RK
AU  - Clark, GM
AU  - O'Leary, SJ
Y2  - 2014/05/22
Y2  - 2009/01/08
Y2  - 2009/01/08
Y2  - 2009/01/08
Y2  - 2009/01/08
Y2  - 2009/01/08
Y2  - 2009/01/08
Y2  - 2009/01/08
Y2  - 2009/01/08
Y2  - 2009/01/08
Y2  - 2009/01/08
Y1  - 2009/05/01
SN  - 0142-9612
UR  - http://hdl.handle.net/11343/33349
AB  - Sensorineural hearing loss is associated with gradual degeneration of spiral ganglion neurons (SGNs), compromising hearing outcomes with cochlear implant use. Combination of neurotrophin delivery to the cochlea and electrical stimulation from a cochlear implant protects SGNs, prompting research into neurotrophin-eluting polymer electrode coatings. The electrically conducting polypyrrole/para-toluene sulfonate containing neurotrophin-3 (Ppy/pTS/NT3) was applied to 1.7 mm2 cochlear implant electrodes. Ppy/pTS/NT3-coated electrode arrays stored 2 ng NT3 and released 0.1 ng/day with electrical stimulation. Guinea pigs were implanted with Ppy/pTS or Ppy/pTS/NT3 electrode arrays two weeks after deafening via aminoglycosides. The electrodes of a subgroup of these guinea pigs were electrically stimulated for 8 h/day for 2 weeks. There was a loss of SGNs in the implanted cochleae of guinea pigs with Ppy/pTS-coated electrodes indicative of electrode insertion damage. However, guinea pigs implanted with electrically stimulated Ppy/pTS/NT3-coated electrodes had lower electrically-evoked auditory brainstem response thresholds and greater SGN densities in implanted cochleae compared to non-implanted cochleae and compared to animals implanted with Ppy/pTS-coated electrodes (p<0.05). Ppy/pTS/NT3 did not exacerbate fibrous tissue formation and did not affect electrode impedance. Drug-eluting conducting polymer coatings on cochlear implant electrodes present a clinically viable method to promote preservation of SGNs without adversely affecting the function of the cochlear implant.
LA  - English
PB  - ELSEVIER SCI LTD
KW  - controlled drug release
KW  - electroactive polymer
KW  - electrode
KW  - electrical stimulation
KW  - neurotrophin
KW  - cochlear implant
T1  - Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons
DO  - 10.1016/j.biomaterials.2009.01.015
IS  - BIOMATERIALS
VL  - 30
IS  - 13
SP  - 2614-2624
ER  -