TY  - GEN
AU  - Wong, Tien Yin
AU  - Larsen, Emily K. Marino
AU  - Klein, Ronald
AU  - MITCHELL, PAUL
AU  - Couper, David J.
AU  - Klein, Barbara E. K.
AU  - Hubbard, Larry D.
AU  - Siscovick, David S.
AU  - Sharrett, A. Richey
Y2  - 2014/05/22
Y1  - 2005
UR  - http://hdl.handle.net/11343/33416
AB  - Objective: To examine the associations of retinal vein occlusion and arteriolar emboli with cardiovascular disease.
                        
                    Design: Population-based cross-sectional study.
                        
                    Participants: Pooled from the Atherosclerosis Risk in Communities Study (n = 12 642; mean age, 60 years) and the Cardiovascular Health Study (n = 2824; mean age, 79 years).
                        
                    Methods: Retinal vein occlusion and arteriolar emboli were identified from a single nonmydriatic retinal photograph using a standardized protocol. Photographs were also graded for arteriovenous nicking and focal arteriolar narrowing. All participants had a comprehensive systemic evaluation, including standardized carotid ultrasonography.
                        
                    Main Outcome Measures: Retinal vein occlusion and arteriolar emboli.
                        
                    Results: Prevalences of retinal vein occlusion and arteriolar emboli were 0.3% (n = 39 cases) and 0.2% (n = 34 cases), respectively. After adjusting for age, retinal vein occlusion was associated with hypertension (odds ratio OR, 2.96; 95% confidence interval CI, 1.43­6.14), systolic blood pressure (BP) (OR, 4.12; 95% CI, 1.40­12.16; highest quartile vs. lowest), diastolic BP (OR, 2.64; 95% CI, 1.07­6.46; highest quartile vs. lowest), carotid artery plaque (OR, 5.62; 95% CI, 2.60­12.16), body mass index (OR, 3.88; 95% CI, 1.23­12.18; highest quartile vs. lowest), plasma fibrinogen (OR, 3.29; 95% CI, 1.08­10.02; highest quartile vs. lowest), arteriovenous nicking (OR, 4.09; 95% CI, 2.00­8.36), and focal arteriolar narrowing (OR, 5.17; 95% CI, 2.59­10.29). After adjusting for age, retinal arteriolar emboli were associated with hypertension (OR, 3.14; 95% CI, 1.44­6.84), systolic BP (OR, 3.46; 95% CI, 1.13­10.65; highest quartile vs. lowest), prevalent coronary heart disease (OR, 2.33! ; 95% CI, 1.01­5.42), carotid artery plaque (OR, 4.62; 95% CI, 1.85­11.57), plasma lipoprotein (a) (OR, 3.6 []
N1  - application/msword
LA  - eng
PB  - Elsevier
KW  - CERA
KW  - ophthalmology
KW  - Centre for Eye Research Australia
KW  - eye research
KW  - vision
KW  - visual health
T1  - Cardiovascular risk factors for retinal vein occlusion and arteriolar emboli: the atherosclerosis risk in communities & cardiovascular health studies
IS  - Ophthalmology: journal of the American Academy of Ophthalmology
VL  - 112
IS  - 4
SP  - 540-547
ER  -