Asia Institute - Research Publications

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ACE1 polymorphism and progression of SARS.

Itoyama, S ; Keicho, N ; Quy, T ; Phi, NC ; Long, HT ; Ha, LD ; Ban, VV ; Ohashi, J ; Hijikata, M ; Matsushita, I ; Kawana, A ; Yanai, H ; Kirikae, T ; Kuratsuji, T ; Sasazuki, T (Elsevier BV, 2004-10-22)

We have hypothesized that genetic predisposition influences the progression of SARS. Angiotensin converting enzyme (ACE1) insertion/deletion (I/D) polymorphism was previously reported to show association with the adult respiratory distress syndrome, which is also thought to play a key role in damaging the lung tissues in SARS cases. This time, the polymorphism was genotyped in 44 Vietnamese SARS cases, with 103 healthy controls who had had a contact with the SARS patients and 50 controls without any contact history. SARS cases were divided into either non-hypoxemic or hypoxemic groups. Despite the small sample size, the frequency of the D allele was significantly higher in the hypoxemic group than in the non-hypoxemic group (p=0.013), whereas there was no significant difference between the SARS cases and controls, irrespective of a contact history. ACE1 might be one of the candidate genes that influence the progression of pneumonia in SARS.
Japanese culture specific face and politeness orientation: A pragmatic investigation of yoroshiku onegaishimasu

Ohashi, J (Walter de Gruyter GmbH, 2003-01-01)