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dc.contributor.authorEtemadi, N
dc.contributor.authorChopin, M
dc.contributor.authorAnderton, H
dc.contributor.authorTanzer, MC
dc.contributor.authorRickard, JA
dc.contributor.authorAbeysekera, W
dc.contributor.authorHall, C
dc.contributor.authorSpall, SK
dc.contributor.authorWang, B
dc.contributor.authorXiong, Y
dc.contributor.authorHla, T
dc.contributor.authorPitson, SM
dc.contributor.authorBonder, CS
dc.contributor.authorWong, WW-L
dc.contributor.authorErnst, M
dc.contributor.authorSmyth, GK
dc.contributor.authorVaux, DL
dc.contributor.authorNutt, SL
dc.contributor.authorNachbur, U
dc.contributor.authorSilke, J
dc.date.accessioned2020-12-22T05:23:19Z
dc.date.available2020-12-22T05:23:19Z
dc.date.issued2015-12-23
dc.identifier.citationEtemadi, N., Chopin, M., Anderton, H., Tanzer, M. C., Rickard, J. A., Abeysekera, W., Hall, C., Spall, S. K., Wang, B., Xiong, Y., Hla, T., Pitson, S. M., Bonder, C. S., Wong, W. W. -L., Ernst, M., Smyth, G. K., Vaux, D. L., Nutt, S. L., Nachbur, U. & Silke, J. (2015). TRAF2 regulates TNF and NF-kappa B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1. ELIFE, 4 (DECEMBER2015), https://doi.org/10.7554/eLife.10592.
dc.identifier.issn2050-084X
dc.identifier.urihttp://hdl.handle.net/11343/258276
dc.description.abstractTRAF2 is a component of TNF superfamily signalling complexes and plays an essential role in the regulation and homeostasis of immune cells. TRAF2 deficient mice die around birth, therefore its role in adult tissues is not well-explored. Furthermore, the role of the TRAF2 RING is controversial. It has been claimed that the atypical TRAF2 RING cannot function as a ubiquitin E3 ligase but counterclaimed that TRAF2 RING requires a co-factor, sphingosine-1-phosphate, that is generated by the enzyme sphingosine kinase 1, to function as an E3 ligase. Keratinocyte-specific deletion of Traf2, but not Sphk1 deficiency, disrupted TNF mediated NF-κB and MAP kinase signalling and caused epidermal hyperplasia and psoriatic skin inflammation. This inflammation was driven by TNF, cell death, non-canonical NF-κB and the adaptive immune system, and might therefore represent a clinically relevant model of psoriasis. TRAF2 therefore has essential tissue specific functions that do not overlap with those of Sphk1.
dc.languageEnglish
dc.publisherELIFE SCIENCES PUBLICATIONS LTD
dc.titleTRAF2 regulates TNF and NF-kappa B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1
dc.typeJournal Article
dc.identifier.doi10.7554/eLife.10592
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.affiliation.departmentSurgery (RMH)
melbourne.affiliation.departmentSchool of Mathematics and Statistics
melbourne.source.titleeLife
melbourne.source.volume4
melbourne.source.issueDECEMBER2015
dc.rights.licenseCC BY
melbourne.elementsid1036563
melbourne.contributor.authorNutt, Stephen
melbourne.contributor.authorVaux, David
melbourne.contributor.authorChopin, Michael
melbourne.contributor.authorAnderton, Holly
melbourne.contributor.authorTanzer, Maria
melbourne.contributor.authorRickard, James
melbourne.contributor.authorSmyth, Gordon
melbourne.contributor.authorNachbur, Ulrich
melbourne.contributor.authorSilke, John
melbourne.contributor.authorErnst, Matthias
dc.identifier.eissn2050-084X
melbourne.accessrightsOpen Access


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