Hematopoietic stem cells, progenitor cells and leukemic stem cells in adult myeloproliferative neoplasms
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2013-05-01
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Leukemia and Lymphoma
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TAYLOR & FRANCIS LTD
Melbourne Authors
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Medicine, Dentistry & Health Sciences - Medical Biology
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Journal Article
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Ng, A. P. (2013). Hematopoietic stem cells, progenitor cells and leukemic stem cells in adult myeloproliferative neoplasms. Leukemia and Lymphoma, 54 (5), pp.922-933. https://doi.org/10.3109/10428194.2012.734615.
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Deposited with permission of the author. © 2012 Dr. Ashley P. Ng
This is a pre-print version, accepted for publication in Leukemia and Lymphoma © 2012, published by Informa Healthcare. http://informahealthcare.com/doi/abs/10.3109/10428194.2012.734615?journalCode=lal
This is a pre-print version, accepted for publication in Leukemia and Lymphoma © 2012, published by Informa Healthcare. http://informahealthcare.com/doi/abs/10.3109/10428194.2012.734615?journalCode=lal
Abstract
The understanding of myeloproliferative neoplasms has changed dramatically since Dameshek proposed his classification over 50 years ago. Our knowledge of the types of cells which constitute the hematopoietic system and of how they are regulated has also appreciated significantly over this time. This review relates what is currently known about the acquired genetic mutations associated with adult myeloproliferative neoplasms to how they lead to the hematopoietic perturbations of myeloproliferative disease. There is a particular focus on how stem and progenitor cell compartments are affected by BCR-ABL1 and JAK2V617F mutations, and the particular issue of resistance of leukemic stem cells to conventional and targeted therapies.
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Keywords
myeloproliferative neoplasms, stem and primitive progenitor cells, signal transduction